Production of recombinant soluble dimeric C-type lectin-like receptors of rat natural killer cells.

ABSTRACT: Working at the border between innate and adaptive immunity, natural killer (NK) cells play a key role in the immune system by protecting healthy cells and by eliminating malignantly transformed, stressed or virally infected cells. NK cell recognition of a target cell is mediated by a receptor "zipper" consisting of various activating and inhibitory receptors, including C-type lectin-like receptors. Among this major group of receptors, two of the largest rodent receptor families are the NKR-P1 and the Clr receptor families. Although these families have been shown to encode receptor-ligand pairs involved in MHC-independent self-nonself discrimination and are a target for immune evasion by tumour cells and viruses, structural mechanisms of their mutual recognition remain less well characteriz

SUBMITTER: Vanek O 

PROVIDER: S-EPMC6882821 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature