The Function of Membrane Integral Pyrophosphatases From Whole Organism to Single Molecule.

ABSTRACT: Membrane integral pyrophosphatases (mPPases) are responsible for the hydrolysis of pyrophosphate. This enzymatic mechanism is coupled to the pumping of H+ or Na+ across membranes in a process that can be K+ dependent or independent. Understanding the movements and dynamics throughout the mPPase catalytic cycle is important, as this knowledge is essential for improving or impeding protein function. mPPases have been shown to play a crucial role in plant maturation and abiotic stress tolerance, and so have the potential to be engineered to improve plant survival, with implications for global food security. mPPases are also selectively toxic drug targets, which could be pharmacologically modulated to reduce the virulence of common human pathogens. The last few years have seen the publication

SUBMITTER: Holmes AOM 

PROVIDER: S-EPMC6882861 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature