Full title: High glucose protects mesenchymal stem cells from metformin-induced apoptosis through the AMPK-mediated mTOR pathway.

ABSTRACT: Micro- and macro-vascular events are directly associated with hyperglycemia in patients with type 2 diabetes mellitus (T₂DM), but whether intensive glucose control decreases the risk of diabetic cardiovascular complications remains uncertain. Many studies have confirmed that impaired quality and quantity of mesenchymal stem cells (MSCs) plays a pathogenic role in diabetes. Our previous study found that the abundance of circulating MSCs was significantly decreased in patients with T₂DM, which was correlated with the progression of diabetic complications. In addition, metformin-induced MSC apoptosis is one of the reasons for the decreased quantity of endogenous or exogenous MSCs during intensive glucose control. However, the role of glucose in metformin-induced MSC apop

SUBMITTER: He X 

PROVIDER: S-EPMC6882892 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature