¹H NMR study of the interaction of trans-resveratrol with soybean phosphatidylcholine liposomes.

ABSTRACT: Resveratrol (RSV) is a well-known natural derivative with a wide range of biological and pharmacological activities. Despite of these demonstrated properties, it exhibits low both aqueous solubility and chemical stability and therefore low bioavailability. Consequently, the major concern of the technological research is to exploit delivery systems able to overcome bioavailability problems. In the recent past liposomes have been successfully studied for these purposes. In this paper, ¹H-NMR spectroscopy, Nuclear Overhauser Spectroscopy (NOESY) as well as Paramagnetic Relaxation Enhancements (PRE) experiments have been carried out to quantitatively investigate the incorporation of resveratrol, at both the liposome preparation stage and by preformed liposomes, also with the aim to

SUBMITTER: Cardia MC 

PROVIDER: S-EPMC6883048 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature