Surgical fat removal exacerbates metabolic disorders but not atherogenesis in LDLR^-/- mice fed on high-fat diet.

ABSTRACT: Lipodystrophy is a severe adipose dysfunction that can be classified as congenital or acquired lipodystrophy, in term of the etiology. Previous knowledge about the metabolic disorders and cardiovascular consequences were mostly obtained from lipodystrophic mice with genetic defects. To completely rule out the genetic influence, we established a mouse model of acquired generalized lipodystrophy by surgical removal of multiple fat depots, including subcutaneous fat in the inguinal, visceral fat in the epididymis and brown fat in the scapula, in atherosclerosis-prone LDLR^-/- mice which were fed with a high-fat diet (HFD). It was observed that fat removal increased diet-induced hyperlipidemia, especially hypercholesteremia, as early as 2 weeks after HFD and till the end of HFD feedi

SUBMITTER: Liu L 

PROVIDER: S-EPMC6883051 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature