Childhood intelligence attenuates the association between biological ageing and health outcomes in later life.

ABSTRACT: The identification of biomarkers that discriminate individual ageing trajectories is a principal target of ageing research. Some of the most promising predictors of biological ageing have been developed using DNA methylation. One recent candidate, which tracks age-related phenotypes in addition to chronological age, is 'DNAm PhenoAge'. Here, we performed a phenome-wide association analysis of this biomarker in a cohort of older adults to assess its relationship with a comprehensive set of both historical, and contemporaneously-measured, phenotypes. Higher than expected DNAm PhenoAge compared with chronological age, known as epigenetic age acceleration, was found to associate with a number of blood, cognitive, physical fitness and lifestyle variables, and with mortality. Notably, DNAm Pheno

SUBMITTER: Stevenson AJ 

PROVIDER: S-EPMC6883059 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature