Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.

ABSTRACT: The incidence of melanoma is increasing over the years with a still poor prognosis and the lack of a cure able to guarantee an adequate survival of patients. Although the new immuno-based coupled to target therapeutic strategy is encouraging, the appearance of targeted/cross-resistance and/or side effects such as autoimmune disorders could limit its clinical use. Alternative therapeutic strategies are therefore urgently needed to efficiently kill melanoma cells. Ferroptosis induction and execution were evaluated in metastasis-derived wild-type and oncogenic BRAF melanoma cells, and the process responsible for the resistance has been dissected at molecular level. Although efficiently induced in all cells, in an oncogenic BRAF- and ER stress-independent way, most cells were resistant to ferr

SUBMITTER: Gagliardi M 

PROVIDER: S-EPMC6883066 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature