The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.

ABSTRACT: Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids^1,2. The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid hydroperoxides into non-toxic lipid alcohols^3,4. Ferroptosis has previously been implicated in the cell death that underlies several degenerative conditions², and induction of ferroptosis by the inhibition of GPX4 has emerged as a therapeutic strategy to trigger cancer cell death⁵. However, sensitivity to GPX4 inhibitors varies greatly across cancer cell lines⁶, which suggests that additional factors govern resistance to ferroptosis. Here, using a synthetic lethal CRISPR-Cas9 screen, we identify ferroptosis s

SUBMITTER: Bersuker K 

PROVIDER: S-EPMC6883167 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature