Monotherapy for Alopecia Areata: A Systematic Review and Network Meta-Analysis.

ABSTRACT:

Background

There are many treatments available for alopecia areata; however, none are approved by the US Food and Drug Administration. Thus, there is clinician benefit in efficacy comparison.

Methods

A network meta-analysis was used to create direct and indirect comparisons of alopecia areata studies in addition to an inconsistency analysis, risk of bias, and quality of evidence assessment.

Results

For mild disease, intralesional corticosteroids were ranked the most likely to produce a response at 78.9% according to SUCRA (surface under the cumulative ranking curve) followed by topical corticosteroids (67.9%), prostaglandin analogs (67.1%), diphenylcyclopropenone (DPCP, 63.4%), topical minoxidil (61.2%), and squaric acid dibutylester (SADBE, 35.0%). In contrast, for m

SUBMITTER: Gupta AK 

PROVIDER: S-EPMC6883433 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature