LINC01128 expedites cervical cancer progression by regulating miR-383-5p/SFN axis.

ABSTRACT: BACKGROUND:Cervical cancer (CC), causing significant morbidity and mortality worldwide, is one of the most common gynecological malignancies in women. SFN has been reported as a potential prognostic marker with apparent high expression in tumors. Nevertheless, the function mechanism of SFN is not clear yet in CC. METHODS:The relative expressions of RNAs were detected by real-time quantitative PCR (RT-qPCR). Colony formation assay, EdU stained assay and CCK-8 assay were to check cell proliferation ability in CC. Flow cytometry and apoptosis related proteins analysis were used to measure cells apoptosis capacity. Luciferase reporter assay and RNA pull down assay were to verify the molecular mechanism. RESULTS:SFN was highly expressed in CC tissues and CC cell lines compared with normal tissu

SUBMITTER: Hu Y 

PROVIDER: S-EPMC6883532 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature