Insulin resistance and systemic metabolic changes in oral glucose tolerance test in 5340 individuals: an interventional study.

ABSTRACT:

Background

Insulin resistance (IR) is predictive for type 2 diabetes and associated with various metabolic abnormalities in fasting conditions. However, limited data are available on how IR affects metabolic responses in a non-fasting setting, yet this is the state people are mostly exposed to during waking hours in the modern society. Here, we aim to comprehensively characterise the metabolic changes in response to an oral glucose test (OGTT) and assess the associations of these changes with IR.

Methods

Blood samples were obtained at 0 (fasting baseline, right before glucose ingestion), 30, 60, and 120 min during the OGTT. Seventy-eight metabolic measures were analysed at each time point for a discovery cohort of 4745 middle-aged Finnish individuals and a replication cohort

SUBMITTER: Wang Q 

PROVIDER: S-EPMC6883544 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature