The dynamics of the inflammatory response during BBN-induced bladder carcinogenesis in mice.

ABSTRACT: BACKGROUND:Bladder cancer (BC) is the most common malignant disease of the urinary tract. Recurrent high grade non muscle invasive BC carries a serious risk for progression and subsequent metastases. The most common preclinical mouse model for bladder cancer relies on administration of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) to mice. BBN-induced tumors in mice recapitulate the histology of human BC and were characterized with an overexpression of markers typical for basal-like cancer subtype in addition to a high mutational burden with frequent mutations in Trp53, similar to human muscle invasive BC. METHODS:Bladder cancer was induced in C57BL/6J male mice by administering the BBN in the drinking water. A thorough histopathological analysis of bladder specimen during and post BBN trea

SUBMITTER: Degoricija M 

PROVIDER: S-EPMC6883615 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature