The impact of cryopreservation on bone marrow-derived mesenchymal stem cells: a systematic review.

ABSTRACT: Mesenchymal stem cells (MSCs) represent an invaluable asset for the field of cell therapy. Human Bone marrow-derived MSCs (hBM-MSCs) are one of the most commonly used cell types in clinical trials. They are currently being studied and tested for the treatment of a wide range of diseases and conditions. The future availability of MSCs therapies to the public will require a robust and reliable delivery process. Cryopreservation represents the gold standard in cell storage and transportation, but its effect on BM-MSCs is still not well established. A systematic review was conducted to evaluate the impact of cryopreservation on BM-MSCs and to attempt to uncover the reasons behind some of the controversial results reported in the literature. Forty-one in vitro studies were analysed, and their r

SUBMITTER: Bahsoun S 

PROVIDER: S-EPMC6883667 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature