Ochratoxin A induces liver inflammation: involvement of intestinal microbiota.

ABSTRACT:

Background

Ochratoxin A (OTA) is a widespread mycotoxin and induces liver inflammation to human and various species of animals. The intestinal microbiota has critical importance in liver inflammation; however, it remains to know whether intestinal microbiota mediates the liver inflammation induced by OTA. Here, we treated ducklings with oral gavage of OTA (235 μg/kg body weight) for 2 weeks. Then, the microbiota in the cecum and liver were analyzed with 16S rRNA sequencing, and the inflammation in the liver was analyzed. To explore the role of intestinal microbiota in OTA-induced liver inflammation, intestinal microbiota was cleared with antibiotics and fecal microbiota transplantation was conducted.

Results

Here, we find that OTA treatment in ducks altered the intestinal mi

SUBMITTER: Wang W 

PROVIDER: S-EPMC6883682 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature