Dysregulation of different classes of tRNA fragments in chronic lymphocytic leukemia.

ABSTRACT: Chronic lymphocytic leukemia (CLL) is the most common human leukemia, and dysregulation of tRNA-derived short noncoding RNA (tsRNA) (tRF-1) expression is an accompanying event in the development of this disease. tsRNAs are fragments originating from the 3' end of tRNA precursors and do not contain mature tRNA sequences. In contrast to tsRNAs, mature tRFs (tRF-3s, tRF-5s, and internal tRFs) are produced from mature tRNA sequences and are redundant fragments. We investigated tsRNA expression in CLL and determined tsRNA signatures in indolent CLL and aggressive CLL vs. normal B cells. We noticed that both ts-43 and ts-44 are derived from distinct genes of pre-tRNA^His, and are down-regulated in CLL 3- to 5-fold vs. normal B cells. Thus, we investigated expression level

SUBMITTER: Veneziano D 

PROVIDER: S-EPMC6883801 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature