Identification of Microenvironment-Related Prognostic Genes in Bladder Cancer Based on Gene Expression Profile.

ABSTRACT: Background and Objective: Bladder cancer is the most common tumor in the urinary system, with a higher incidence in men than in women and a high recurrence rate. However, the mechanism of recurrence is still unclear, and it is urgent to clarify the pathophysiological mechanism of bladder cancer. To provide theoretical basis for the development of new therapies, investigating the effect of tumor microenvironment on the prognosis of bladder cancer is necessary. Methods: We applied the Estimation of STromal and Immune cells in MAlignant Tumors using Expression data (ESTIMATE) algorithm to the downloaded TCGA (The Cancer Genome Atlas) transcriptome data to obtain the immune scores and stromal scores of each sample, and then divided the samples into two groups: high and low immune

SUBMITTER: Luo Y 

PROVIDER: S-EPMC6883806 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature