Overexpression and Selective Anticancer Efficacy of ENO3 in STK11 Mutant Lung Cancers.

ABSTRACT: Oncogenic gain-of-function mutations are clinical biomarkers for most targeted therapies, as well as represent direct targets for drug treatment. Although loss-of-function mutations involving the tumor suppressor gene, STK11 (LKB1) are important in lung cancer progression, STK11 is not the direct target for anticancer agents. We attempted to identify cancer transcriptome signatures associated with STK11 loss-offunction mutations. Several new sensitive and specific gene expression markers (ENO3, TTC39C, LGALS3, and MAML2) were identified using two orthogonal measures, i.e., fold change and odds ratio analyses of transcriptome data from cell lines and tissue samples. Among the markers identified, the ENO3 gene over-expression was found to be the dire

SUBMITTER: Park C 

PROVIDER: S-EPMC6883975 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature