Development and Validation of a Nomogram for Early Detection of Malignant Gallbladder Lesions.

ABSTRACT:

Objectives

Preoperative decision-making for differentiating malignant from benign lesions in the gallbladder remains challenging. We aimed to create a diagnostic nomogram to identify gallbladder cancer (GBC), especially for incidental GBC (IGBC), before surgical resection.

Methods

A total of 587 consecutive patients with pathologically confirmed gallbladder lesions from a hospital were randomly assigned to a training cohort (70%) and an internal validation cohort (30%), with 287 patients from other centers as an external validation cohort. Radiological features were developed by the least absolute shrinkage and selection operator logistic regression model. Significant radiological features and independent clinical factors, identified by multivariate analyses, were used to co

SUBMITTER: Chen M 

PROVIDER: S-EPMC6884352 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature