Quantitative firing pattern phenotyping of hippocampal neuron types.

ABSTRACT: Systematically organizing the anatomical, molecular, and physiological properties of cortical neurons is important for understanding their computational functions. Hippocampome.org defines 122 neuron types in the rodent hippocampal formation based on their somatic, axonal, and dendritic locations, putative excitatory/inhibitory outputs, molecular marker expression, and biophysical properties. We augmented the electrophysiological data of this knowledge base by collecting, quantifying, and analyzing the firing responses to depolarizing current injections for every hippocampal neuron type from published experiments. We designed and implemented objective protocols to classify firing patterns based on 5 transients (delay, adapting spiking, rapidly adapting spiking, transient stuttering, and tr

SUBMITTER: Komendantov AO 

PROVIDER: S-EPMC6884469 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature