Differential DNA methylation in high-grade serous ovarian cancer (HGSOC) is associated with tumor behavior.

ABSTRACT: The epigenome offers an additional facet of cancer that can help categorize patients into those at risk of disease, recurrence, or treatment failure. We conducted a retrospective, nested, case-control study of advanced and recurrent high-grade serous ovarian cancer (HGSOC) patients in which we assessed epigenome-wide association using Illumina methylationEPIC arrays to characterize DNA methylation status and RNAseq to evaluate gene expression. Comparing HGSOC tumors with normal fallopian tube tissues we observe global hypomethylation but with skewing towards hypermethylation when interrogating gene promoters. In total, 5,852 gene interrogating probes revealed significantly different methylation. Within HGSOC, 57 probes highlighting 17 genes displayed significant differential DNA methylatio

SUBMITTER: Reyes HD 

PROVIDER: S-EPMC6884482 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature