Isolation and comparative genomics of Mycobacterium tuberculosis isolates from cattle and their attendants in South India.

ABSTRACT: The major human pathogen Mycobacterium tuberculosis is rarely reported to cause disease in other animals. Cases in livestock are thought to occur through contact with infected handlers, but previous studies evaluating putative livestock-human transmission used typing techniques with limited resolution. Here, we undertook cross-sectional surveillance for tuberculosis in 271 livestock handlers and 167 cattle on three farms in Chennai, India and defined the relatedness of cultured isolates using whole genome sequencing. Humans and livestock were screened for active mycobacterial infection, and opportunistic post-mortem examination was performed on comparative intradermal test-positive cattle that died. Four cattle and 6 handlers on two farms were culture-positive for M. tuberculosis; M. bovis

SUBMITTER: Palaniyandi K 

PROVIDER: S-EPMC6884536 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature