Thymic-specific regulation of TCR signaling by Tespa1.

ABSTRACT: Double-positive (DP) thymocytes undergo positive selection to become mature single-positive CD4⁺ and CD8⁺ T cells in response to T cell receptor (TCR) signaling. Unlike mature T cells, DP cells must respond to low-affinity self-peptide-MHC ligands before full upregulation of their surface TCR expression can occur. Thus, DP thymocytes must be more sensitive to ligands than mature T cells. A number of molecules have been found that are able to enhance the strength of the TCR signal to facilitate positive selection. However, almost all of these molecules are also active in mature T cells. Themis (thymocyte expressed molecule involved in selection) and Tespa1 (thymocyte expressed positive selection associated 1) are two recently discovered molecules essential for optimal

SUBMITTER: Lyu J 

PROVIDER: S-EPMC6884599 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature