Dengue infection in mice inoculated by the intracerebral route: neuropathological effects and identification of target cells for virus replication.

ABSTRACT: Dengue is an important arboviral infection, causing a broad range symptom that varies from life-threatening mild illness to severe clinical manifestations. Recent studies reported the impairment of the central nervous system (CNS) after dengue infection, a characteristic previously considered as atypical and underreported. However, little is known about the neuropathology associated to dengue. Since animal models are important tools for helping to understand the dengue pathogenesis, including neurological damages, the aim of this work was to investigate the effects of intracerebral inoculation of a neuroadapted dengue serotype 2 virus (DENV2) in immunocompetent BALB/c mice, mimicking some aspects of the viral encephalitis. Mice presented neurological morbidity after the 7^th day

SUBMITTER: Amorim JFS 

PROVIDER: S-EPMC6884643 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature