The nuclear receptor seven up functions in adipocytes and oenocytes to control distinct steps of Drosophila oogenesis.

ABSTRACT: Reproduction is intimately linked to the physiology of an organism. Nuclear receptors are widely expressed transcription factors that mediate the effects of many circulating molecules on physiology and reproduction. While multiple studies have focused on the roles of nuclear receptors intrinsically in the ovary, it remains largely unknown how the actions of nuclear receptors in peripheral tissues influence oogenesis. We identified the nuclear receptor encoded by svp as a novel regulator of oogenesis in adult Drosophila. Global somatic knockdown of svp reduces egg production by increasing GSC loss, death of early germline cysts, and degeneration of vitellogenic follicles. Tissue-specific knockdown experiments revealed that svp remotely controls these different steps of oogenesis through sep

SUBMITTER: Weaver LN 

PROVIDER: S-EPMC6884690 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature