Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants.

ABSTRACT: The exome sequences of approximately 8,000 children with autism spectrum disorder (ASD) and/or attention deficit hyperactivity disorder (ADHD) and 5,000 controls were analyzed, finding that individuals with ASD and individuals with ADHD had a similar burden of rare protein-truncating variants in evolutionarily constrained genes, both significantly higher than controls. This motivated a combined analysis across ASD and ADHD, identifying microtubule-associated protein 1A (MAP1A) as a new exome-wide significant gene conferring risk for childhood psychiatric disorders.

SUBMITTER: Satterstrom FK 

PROVIDER: S-EPMC6884695 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature