Inhibition of microglial activation in rats attenuates paraventricular nucleus inflammation in Gαi₂ protein-dependent, salt-sensitive hypertension.

ABSTRACT:

New findings

• What is the central question of this study? We hypothesized that central inflammatory processes that involve activation of microglia and astrocytes contribute to the development of Gαi₂ protein-dependent, salt-sensitive hypertension. • What is the main finding and its importance? The main finding is that PVN-specific inflammatory processes, driven by microglial activation, appear to be linked to the development of Gαi₂ protein-dependent, salt-sensitive hypertension in Sprague-Dawley rats. This finding might reveal new mechanistic targets in the treatment of hypertension.

Abstract

The central mechanisms underlying salt-sensitive hypertension, a significant public health issue, remain to be established. Researchers in our laboratory have re

SUBMITTER: Moreira JD 

PROVIDER: S-EPMC6884700 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature