Stem cells from human cardiac adipose tissue depots show different gene expression and functional capacities.

ABSTRACT:

Background

The composition and function of the adipose tissue covering the heart are poorly known. In this study, we have investigated the epicardial adipose tissue (EAT) covering the cardiac ventricular muscle and the EAT covering the left anterior descending artery (LAD) on the human heart, to identify their resident stem cell functional activity.

Methods

EAT covering the cardiac ventricular muscle was isolated from the apex (avoiding areas irrigated by major vessels) of the heart (ventricular myocardium adipose tissue (VMAT)) and from the area covering the epicardial arterial sulcus of the LAD (PVAT) in human hearts excised during heart transplant surgery. Adipose stem cells (ASCs) from both adipose tissue depots were immediately isolated and phenotypically characterized

SUBMITTER: Lambert C 

PROVIDER: S-EPMC6884762 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature