Tumor treating fields in the management of Glioblastoma: opportunities for advanced imaging.

ABSTRACT: Alternating electric fields have been successfully applied to cancer cells in-vitro to disrupt malignant progression and this antimitotic therapy has now been proven to be efficacious in Phase II and Phase III randomized clinical trials of patients with glioblastoma. With additional clinical trials ongoing in a number of other malignancies, there is a crucial need for a better understanding of the radiographic predictors of response and standardization of surveillance imaging interpretation. However, many radiologists have yet to become familiarized with this emerging cancer therapy and there is little active investigation to develop prognostic or predictive imaging biomarkers. This article provides an overview of the pre-clinical data that elucidate the biologic mechanisms of alternating

SUBMITTER: Soni VS 

PROVIDER: S-EPMC6884888 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature