Comparative metabolomic analysis reveals the variations in taxoids and flavonoids among three Taxus species.

ABSTRACT: BACKGROUND:Trees of the genus Taxus are highly valuable medicinal plants with multiple pharmacological effects on various cancer treatments. Paclitaxel from Taxus trees is an efficient and widely used anticancer drug, however, the accumulation of taxoids and other active ingredients can vary greatly among Taxus species. In our study, the metabolomes of three Taxus species have been investigated. RESULTS:A total of 2246 metabolites assigned to various primary and secondary metabolic pathways were identified using an untargeted approach. Analysis of differentially accumulated metabolites identified 358 T. media-, 220 T. cuspidata-, and 169 T. mairei-specific accumulated metabolites, respectively. By searching the metabolite pool, 7 MEP pathway precursors, 11 intermediates, side chain product

SUBMITTER: Zhou T 

PROVIDER: S-EPMC6884900 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature