Cross-talk between SIM2s and NFκB regulates cyclooxygenase 2 expression in breast cancer.

ABSTRACT:

Background

Breast cancer is a leading cause of cancer-related death for women in the USA. Thus, there is an increasing need to investigate novel prognostic markers and therapeutic methods. Inflammation raises challenges in treating and preventing the spread of breast cancer. Specifically, the nuclear factor kappa b (NFκB) pathway contributes to cancer progression by stimulating proliferation and preventing apoptosis. One target gene of this pathway is PTGS2, which encodes for cyclooxygenase 2 (COX-2) and is upregulated in 40% of human breast carcinomas. COX-2 is an enzyme involved in the production of prostaglandins, which mediate inflammation. Here, we investigate the effect of Singleminded-2s (SIM2s), a transcriptional tumor suppressor that is implicated in inhibition of tumor gr

SUBMITTER: Wyatt GL 

PROVIDER: S-EPMC6884910 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature