Common genetic variation and risk of osteosarcoma in a multi-ethnic pediatric and adolescent population.

ABSTRACT: Osteosarcoma, a malignant primary bone tumor most commonly diagnosed in children and adolescents, has a poorly understood genetic etiology. Genome-wide association studies (GWAS) and candidate-gene analyses have identified putative risk variants in subjects of European ancestry. However, despite higher incidence among African-American and Hispanic children, little is known regarding common heritable variation that contributes to osteosarcoma incidence and clinical presentation across racial/ethnic groups. In a multi-ethnic sample of non-Hispanic white, Hispanic, African-American and Asian/Pacific Islander children (537 cases, 2165 controls), we performed association analyses assessing previously-reported loci for osteosarcoma risk and metastasis, including meta-analysis across racial/ethni

SUBMITTER: Zhang C 

PROVIDER: S-EPMC6885126 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature