Dexmedetomidine Attenuates Orthotopic Liver Transplantation-Induced Acute Gut Injury via α ₂-Adrenergic Receptor-Dependent Suppression of Oxidative Stress.

ABSTRACT: Patients with orthotopic liver transplantation (OLT) frequently develop acute gut injury (AGI), and dexmedetomidine (Dex) has been reported to exert a protective effect against AGI. We investigated whether Dex protects against AGI through antioxidative stress effects by the Nrf2/HO-1 antioxidative signaling pathway. Rats were randomly allocated into a sham group and six orthotopic autologous liver transplantation (OALT) groups receiving different doses of Dex together with/without α ₂-adrenergic receptor (AR) blockers. Intestinal tissues were collected to visualize the barrier damage and to measure the indexes of oxidative stress. For in vitro studies, rat intestinal recess epithelial cells (IEC-6) underwent hypoxia/reoxygenation (H/R), and the protective role of D

SUBMITTER: Lv P 

PROVIDER: S-EPMC6885230 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature