Analysis of miRNA expression profiles in the liver of Clock ^Δ19 mutant mice.

ABSTRACT: The circadian clock controls the physiological functions of many tissues including the liver via an autoregulatory transcriptional-translational feedback loop, of which CLOCK is a core positive component. In addition, many studies have indicated that microRNAs (miRNAs) regulate liver function. However, how CLOCK-regulated miRNAs are linked to liver function remains largely unknown. In this study, miRNAs expression profiles were performed in the liver of Clock ^Δ19 mutant mice. Compared to wild type mice, totals of 61 and 57 putative CLOCK-regulated miRNAs were differentially expressed (fold change absolute value ≥2) at zeitgeber time 2 and zeitgeber time 14, respectively. According to the pathway analyses, the target genes of differentially expressed miRNAs were mainly inv

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6885354 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature