Gender associated effects of the ethanolic extracts of Chinese propolis on the hepatic transcriptome in ethanol-treated mice.

ABSTRACT:

Objectives

The current study investigated the potential hepatoprotective effects of the ethanolic extracts of Chinese propolis (EECP) on ethanol-induced fatty liver in mice.

Materials and methods

C57BL/6J mice were orally gavaged with 50% ethanol alone or co-administrated with EECP at the dose of 0.2 ml/kg bodyweight for eight weeks. The dose for ethanol was 6 ml/kg bodyweight for the first two experimental weeks, and then increased to 8, 10, and 12 ml/kg bodyweight every two experimental weeks. Alterations in the hepatic transcriptome due to concomitant administration of EECP were investigated using RNA-Seq technique.

Results

Our results showed that the main EECP-responsive genes were involved in lipid syntheses, which were significantly down-regulated in both female

SUBMITTER: Ye M 

PROVIDER: S-EPMC6885388 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature