Association between cytokines and two circulating micro-RNAs and development of premature ventricular contractions-induced cardiomyopathy.

ABSTRACT:

Objectives

Recent progress in understanding the pathogenesis of premature ventricular contraction (PVC)-induced cardiomyopathy (PIC) has suggested a key role for inflammation. The aim of this study was to evaluate the expression of messenger RNAs (mRNAs) and the protein production of interleukin-6 (IL-6), IL-10, tumor necrosis factor alpha (TNF-α) and interferon-γ (IFN-γ) and two circulating micro-RNAs related to inflammation and cardiovascular disease; miR-155 and miR-146.

Materials and methods

The study population was comprised 25 patients with PIC and 25 patients with normal left ventricular ejection fraction despite frequent PVCs. TNF-α, IL-6, IL10, and IFN-γ levels were evaluated in peripheral blood mononuclear cells (PBMCs) by flow cytometry and their mRNAs were assess

SUBMITTER: Ghadrdoost B 

PROVIDER: S-EPMC6885395 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature