Therapeutic-induced hypertension in patients with noncardioembolic acute stroke.

ABSTRACT: OBJECTIVE:To evaluate the safety and efficacy of induced hypertension in patients with acute ischemic stroke. METHODS:In this multicenter randomized clinical trial, patients with acute noncardioembolic ischemic stroke within 24 hours of onset who were ineligible for revascularization therapy and those with progressive stroke during hospitalization were randomly assigned (1:1) to the control and intervention groups. In the intervention group, phenylephrine was administered intravenously to increase systolic blood pressure (SBP) up to 200 mm Hg. The primary efficacy endpoint was early neurologic improvement (reduction in NIH Stroke Scale [NIHSS] score of ≥2 points during the first 7 days). The secondary efficacy endpoint was a modified Rankin Scale score of 0 to 2 at 90 days. Safety outcomes

SUBMITTER: Bang OY 

PROVIDER: S-EPMC6885575 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature