Implications of genetic diagnostics in epilepsy surgery candidates: A single-center cohort study.

ABSTRACT:

Objective

Genetic causes are increasingly identified in patients with focal epilepsy. These genetic causes may be related to the effectiveness of epilepsy surgery. We aimed to assess the use and yield of genetic testing in a large cohort of patients who were evaluated for epilepsy surgery.

Methods

We performed a retrospective single-center consecutive cohort study of patients who were evaluated for surgery between 1990 and 2016. Within this cohort, we assessed the use of genetic testing-either before or after presurgical decision-making. We evaluated genetic results as well as the outcome of presurgical decision-making and surgery, and compared these end points for different subgroups-especially MRI-positive vs MRI-negative patients. Patients with tuberous sclerosis (

SUBMITTER: Sanders MWCB 

PROVIDER: S-EPMC6885658 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature