Genomic and clinical predictors of lacosamide response in refractory epilepsies.

ABSTRACT:

Objective

Clinical and genetic predictors of response to antiepileptic drugs (AEDs) are largely unknown. We examined predictors of lacosamide response in a real-world clinical setting.

Methods

We tested the association of clinical predictors with treatment response using regression modeling in a cohort of people with refractory epilepsy. Genetic assessment for lacosamide response was conducted via genome-wide association studies and exome studies, comprising 281 candidate genes.

Results

Most patients (479/483) were treated with LCM in addition to other AEDs. Our results corroborate previous findings that patients with refractory genetic generalized epilepsy (GGE) may respond to treatment with LCM. No clear clinical predictors were identified. We then compared 73 lacos

SUBMITTER: Heavin SB 

PROVIDER: S-EPMC6885661 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature