Acute metabolic effects of tonic-clonic seizures.

ABSTRACT:

Objective

Tonic-clonic seizures (TCS) lead to metabolic stress and changes in related blood markers. Such markers may indicate harmful conditions but can also help to identify TCS as a cause of transient loss of consciousness. In this study, we hypothesized that the alterations of circulating markers of metabolic stress depend on the clinical features of TCS.

Methods

Ninety-one adults undergoing video-EEG monitoring participated in this prospective study. Electrolytes, renal parameters, creatine kinase (CK), prolactin (PRL), lactate, ammonia, glucose, and other parameters were measured at inclusion and different time points after TCS.

Results

A total of 39 TCS were recorded in 32 patients (six generalized onset tonic-clonic seizures in 6 and 33 focal to bilateral toni

SUBMITTER: Nass RD 

PROVIDER: S-EPMC6885665 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature