Regional hippocampal diffusion abnormalities associated with subfield-specific pathology in temporal lobe epilepsy.

ABSTRACT:

Objective

Hippocampal sclerosis (HS) is the most common pathology and best predictor of surgical outcome for medically refractory patients with temporal lobe epilepsy (TLE). Current clinical MRI methods can detect HS, but subfield pathology is poorly characterized, limiting accurate prediction of seizure-free outcomes after surgery. Diffusion tensor imaging (DTI) can probe regional microstructural changes associated with focal hippocampal pathology, but is typically limited by low-resolution whole-brain acquisitions.

Methods

High-resolution (1 × 1 × 1 mm³) DTI, T1, and quantitative T2 of the hippocampus was acquired in 18 preoperative TLE patients and 19 healthy controls. Diffusion images were qualitatively assessed for loss of internal architecture, and whole-hip

SUBMITTER: Treit S 

PROVIDER: S-EPMC6885671 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature