The landscape of immune microenvironment in lung adenocarcinoma and squamous cell carcinoma based on PD-L1 expression and tumor-infiltrating lymphocytes.

ABSTRACT:

Aims

The aim of this study was to investigate the tumor microenvironment immune types (TMIT) based on tumor cell programmed cell death ligand 1 (PD-L1) expression and tumor-infiltrating lymphocytes (TILs) distribution and whether distinct TMIT subtypes (TMIT I, PD-L1^high /TIL^high ; TMIT II, PD-L1^low /TIL^low ; TMIT III, PD-L1^high /TIL^low ; and TMIT IV, PD-L1^low /TIL^high ) differentially affect clinical outcomes of patients with lung adenocarcinoma (LAC) and squamous cell carcinoma (SCC).

Methods and results

Immunohistochemistry (IHC) was applied to evaluate the expression of PD-L1 and the spatial distribution of programmed cell death 1 (PD-1) and CD8 TILs on the surgically resected specime

SUBMITTER: Chen L 

PROVIDER: S-EPMC6885882 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature