Pharmacogenetic analyses of variations of measures of cardiovascular risk in Alzheimer's dementia.

ABSTRACT:

Background & objectives

Neurodegeneration affects blood pressure variations, while renal function and cerebral perfusion are impaired by vascular risk factors. This study was aimed to estimate variations of measures of cardiovascular risk in Alzheimer's dementia by pharmacogenetic analyses of the effects of angiotensin-converting enzyme (ACE) inhibitors and statins.

Methods

Consecutive patients were prospectively followed to study variations of creatinine clearance and blood pressure for one year, estimated by correlating the effects of ACE inhibitors with the ACE Alu I/D polymorphism and genotypes or haplotypes of rs1800764 or rs4291, and the effects of statins with LDLR (low-density lipoprotein receptor) genotypes or haplotypes of rs11669576 (exon 8) or rs5930 (exon 10), o

SUBMITTER: de Oliveira FF 

PROVIDER: S-EPMC6886147 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature