Exploring the 2D and 3D structural properties of topologically associating domains.

ABSTRACT:

Background

Topologically associating domains (TADs) are genomic regions with varying lengths. The interactions within TADs are more frequent than those between different TADs. TADs or sub-TADs are considered the structural and functional units of the mammalian genomes. Although TADs are important for understanding how genomes function, we have limited knowledge about their 3D structural properties.

Results

In this study, we designed and benchmarked three metrics for capturing the three-dimensional and two-dimensional structural signatures of TADs, which can help better understand TADs' structural properties and the relationships between structural properties and genetic and epigenetic features. The first metric for capturing 3D structural properties is radius of gyration, wh

SUBMITTER: Liu T 

PROVIDER: S-EPMC6886161 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature