Transcranial magnetic stimulation and amyloid markers in mild cognitive impairment: impact on diagnostic confidence and diagnostic accuracy.

ABSTRACT:

Background

The development of diagnostic tools capable of accurately identifying the pathophysiology of mild cognitive impairment (MCI) has become a crucial target considering the claim that disease-modifying treatments should be administered as early as possible in the disease course. Transcranial magnetic stimulation (TMS) protocols have demonstrated analytical validity in discriminating different forms of dementia; however, its value in daily clinical practice in MCI subjects is still unknown.

Objective

To evaluate the clinical value of TMS compared to amyloid markers on diagnostic confidence and accuracy in MCI subjects, considering clinicians' expertise.

Methods

One hundred seven MCI subjects were included and classified as MCI-Alzheimer disease (MCI-AD), MCI-fro

SUBMITTER: Padovani A 

PROVIDER: S-EPMC6886207 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature