Ontology highlight
ABSTRACT:
SUBMITTER: Kimmel JC
PROVIDER: S-EPMC6886498 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Kimmel Jacob C JC Penland Lolita L Rubinstein Nimrod D ND Hendrickson David G DG Kelley David R DR Rosenthal Adam Z AZ
Genome research 20191121 12
Aging is a pleiotropic process affecting many aspects of mammalian physiology. Mammals are composed of distinct cell type identities and tissue environments, but the influence of these cell identities and environments on the trajectory of aging in individual cells remains unclear. Here, we performed single-cell RNA-seq on >50,000 individual cells across three tissues in young and old mice to allow for direct comparison of aging phenotypes across cell types. We found transcriptional features of a ...[more]