Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells.

ABSTRACT: An abnormal number of chromosomes, or aneuploidy, accounts for most spontaneous abortions, causes developmental defects, and is associated with aging and cancer. The molecular mechanisms by which aneuploidy disrupts cellular function remain largely unknown. Here, we show that aneuploidy disrupts the morphology of the nucleus. Mutations that increase the levels of long-chain bases suppress nuclear abnormalities of aneuploid yeast independent of karyotype identity. Quantitative lipidomics indicates that long-chain bases are integral components of the nuclear membrane in yeast. Cells isolated from patients with Down syndrome also show that abnormal nuclear morphologies and increases in long-chain bases not only suppress these abnormalities but also improve their fitness. We obtained similar r

SUBMITTER: Hwang S 

PROVIDER: S-EPMC6886690 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature