Sexually Dimorphic Influence of Neonatal Antibiotics on Bone.

ABSTRACT: The gut microbiome (GM) contributes to host development, metabolism, and disease. Perturbations in GM composition, elicited through chronic administration of oral antibiotics (Abx) or studied using germ-free environments, alter bone mass, and microarchitecture. However, studies primarily involved chronic Abx exposure to adult mice prior to evaluating the skeletal phenotype. Children are more prone to infection with bacterial pathogens than adults and are thus treated more frequently with broad-spectrum Abx; consequently, Abx treatment disproportionately occurs during periods of greatest skeletal plasticity to anabolic cues. Because early-life exposures may exert long-lasting effects on adult health, we hypothesized that acute Abx administration during a developmentally sensitive period wou

SUBMITTER: Pusceddu MM 

PROVIDER: S-EPMC6886746 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature