Pubertal timing and adult fracture risk in men: A population-based cohort study.

ABSTRACT:

Background

Puberty is a critical period for bone mass accrual, and late puberty in boys is associated with reduced bone mass in adult men. The role of variations in pubertal timing within the normal range for adult fracture risk in men is, however, unknown. We, therefore, assessed the association between age at peak height velocity (PHV), an objective measure of pubertal timing, and fracture risk in adult men.

Methods and findings

In the BMI Epidemiology Study Gothenburg, 31,971 Swedish men born between January 1, 1945, and December 31, 1961, with detailed growth data (height and weight) available from centrally archived school healthcare records and the conscription register were followed until December 31, 2016. Age at PHV was calculated according to a modified infancy-chi

SUBMITTER: Vandenput L 

PROVIDER: S-EPMC6886748 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature