Maternal prescribed opioid analgesic use during pregnancy and associations with adverse birth outcomes: A population-based study.

ABSTRACT:

Background

Published research on prescribed opioid analgesic (POA) use during pregnancy and birth outcomes is limited in scope and has not adequately adjusted for potential confounding factors. To help address these gaps, we estimated associations between maternal POAs during pregnancy and two adverse birth outcomes using a large population-based dataset, multiple definitions of POA exposure, and several methods to evaluate the influence of both measured and unmeasured confounding factors.

Methods and findings

We obtained data by linking information from several Swedish registers and conducted a retrospective cohort study on a population-based sample of 620,458 Swedish births occurring between 2007 and 2013 (48.6% female; 44.4% firstborn). We evaluated associations between p

SUBMITTER: Sujan AC 

PROVIDER: S-EPMC6886755 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature