Photodamage repair pathways contribute to the accurate maintenance of the DNA methylome landscape upon UV exposure.

ABSTRACT: Plants are exposed to the damaging effect of sunlight that induces DNA photolesions. In order to maintain genome integrity, specific DNA repair pathways are mobilized. Upon removal of UV-induced DNA lesions, the accurate re-establishment of epigenome landscape is expected to be a prominent step of these DNA repair pathways. However, it remains poorly documented whether DNA methylation is accurately maintained at photodamaged sites and how photodamage repair pathways contribute to the maintenance of genome/methylome integrities. Using genome wide approaches, we report that UV-C irradiation leads to CHH DNA methylation changes. We identified that the specific DNA repair pathways involved in the repair of UV-induced DNA lesions, Direct Repair (DR), Global Genome Repair (GGR) and small RNA-med

SUBMITTER: Graindorge S 

PROVIDER: S-EPMC6886878 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature